They respawn in the Varrock Sewers, which is marked on your mini map as a red exclamation mark, just North of the East Varrock Bank.

Once you enter the sewers travel all the way to the end and you will find the red spider eggs, if you're a lower level, avoide getting close to the moss giants. Red Spider eggs are worth 330+ GP each, which is about 9240 gp per trip.
It is a slow way of making money, but it requires no skill, and is good for lower levels.
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